종양억제분자구조 연구실

We are interested in understanding the molecular mechanisms of signal transduction by various GPCRs and tyrosine kinase receptors. These signaling pathways are related with various metabolisms including perception, neurotransmitter, sensing tastes, hearing and many other cellular and physiological functions. We are particularly interested in deorphanizing the orphan GPCRs. By doing so, we can find out novel agonists/antagonists/inverse agonists and make it possible to regulate the function of GPCRs and other receptors and provide important clues to cure the receptor-related diseases. Our studies also allow us to generate antibodies and aptamers that bind and control the functions of these receptors. We are currently working on GPCRs that are involved in tumorigenesis and neurodegenerative diseases.