분자인지구조생물학 연구실

우리 실험실에서는 서로 다른 단백질간, 단백질과 기질간 또는 단백질과 DNA간의 상호작용을 생화학적, 구조생물학적 방법을 통해 밝힘으로써, 생체내에서 일어나는 일련의 신호전달 활성화 과정을 분자 수준에서 이해 하고자 합니다. 이에 대한 정보를 바탕으로 각종 질병에서 일어나는 비이상적 상호작용을 설명하고, 이를 조절할수 있는 방법 개발하고자 합니다. The growth and replication of living eukaryotic cells are regulated by lots of signals from outside and also from inside. Cell receives various signals from other cells by messengers, such as growth factor, which are recognized by cell surface receptors. On the other hands, inside of cell, intensive signals keep firing throughout the multiple networks to process/response the signal from outside and to check/maintain the correct metabolism of cells (ex. DNA replication, DNA damage response) and to monitor physiological stress of cells (ex. nutrient depletion). These inside-cell signaling networks are often composed of sensor, switch, adaptor, transducer and effector, like a sophisticated electric machine. Among these components, a few numbers of molecular switches control the lots of cellular process. Interestingly, these molecular switches can also integrated the information from sensor and determine the responses. Any unexpected disruption of these signaling pathway is responsible for human disease. The main goal of our research is to understand the detailed molecular mechanisms of molecular switch (ex, PIKK members) networks in the DNA damage response, by using both structural and biochemical approaches. Base on this information, we wish to provide fundamental understating of acting and controlling mechanism of molecular switches, which can lead to potential drug design. The adaptive immune response in vertebrates has almost unlimited repertoire of immunoglobulins and T cell receptors which is generated by combinatorial rearrangement of an extensive array of variable (V), div