Gene Silencing Lab

MicroRNA miR-315-5p regulates developmental growth in Drosophila wings by targeting S6k. MicroRNA miR-199a-3p alleviates liver fibrosis by targeting CDK17 in activated hepatic stellate cells. A multi-layered network expansion model identifies Akt1 as common modulator of neurodegenertaion. MicroRNA miR-252-5p regulates the Notch signaling pathway by targeting Rab6 in Drosophila wing development. The conserved microRNA miR-8-3p coordinates the expression of V-ATPase subunits to regulate ecdysone biosynthesis for Drosophila metamorphosis. Phc2 controls hematopoietic stem and progenitor cell mobilization from bone marrow by repressing Vcam1 expression. MicroRNA miR-252 targets mbt to control the developmental growth of Drosophila. Ecdysone-responsive microRNA-252-5p controls the cell cycle by targeting Abi in Drosophila. MicroRNA signatures associated with thioacetamide-induced liver fibrosis in mice. Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice. Glycolaldehyde-derived advanced glycation end products (glycol-AGEs)-induced vascular smooth muscle cell dysfunction is regulated by the AGES-receptor (RAGE) axis in endothelium. TrpA1 regulates defecation of food-borne pathogens under the control of the Duox pathway. A polymorphism in the porcine miR-208b is associated with microRNA biogenesis and expressions of SOX-6 and MYH7 with effects on muscle fibre characteristics and meat quality. Changes in cellular microRNA expression induced by porcine circovirus type 2-encoded proteins. Genome-wide microRNA expression profiling in placentas of fetuses with Down syndrome. Trafficking of LAG-3 to the surface on activated T cells via its cytoplasmic domain and protein kinase C signaling. Global iden