RNA 유전체 조절 연구실

We delve into the fascinating world of long noncoding RNAs (lncRNAs) and their pivotal role in shaping the 3D epigenome dynamics. We aim to unravel the mechanisms of how dysregulated lncRNAs and alterations in chromatin topology lead to pathogenesis. We use embryonic stem cell models, coupled with functional perturbation techniques and multi-omics approach. We explore the spatial organization of the mammalian genome across various levels. Our aim is to uncover the mechanisms regulating the formation and dynamic alteration of chromosome loops in the 3D genome, with a specific focus on RNA-directed mechanisms. LncRNAs hold the key to understanding the mechanisms that govern highly regulated gene expression in complex organisms. However, their functions largely await exploration. We aim to understand the biology of lncRNAs and the mechanisms of their actions. To achieve our goals, we use epigenomics, transcriptomics, proteomics, 3C-based technologies, and bioinformatics.