Chromatin Organization·Decoding·Engineering (CODE) Lab (크로마틴 해독·설계 연구실)

Reading the grammar of chromatin regulation — and learning to rewrite it — to build the next generation of gene and epigenome engineering tools. Chromatin — its 3D folding and its epigenetic state — sets the rules of gene regulation. CODE Lab works to read those rules and rewrite them. We observe chromatin organization directly, in single cells, to understand how 3D structure and epigenetic modifications control gene expression, and we turn that understanding into precise, programmable tools for genome and epigenome control. Discovery is led by ORCA-based multimodal spatial imaging of DNA, RNA, and protein, complemented by bottom-up synthetic biology that rebuilds regulatory logic from minimal parts. What is chromatin actually doing?We observe chromatin where it acts, in single cells. Our flagship is ORCA-based multimodal spatial imaging of DNA, RNA, and protein in the same cell — backed by spatial transcriptomics, flow cytometry, qPCR, Western blotting, nanopore and next-generation sequencing. What rules explain it?Using bottom-up synthetic biology, we rebuild epigenetic regulation from minimal parts to find the principles — the read–write logic and memory — sufficient to explain it, supported by computational modeling. Can we program it?We build what the rules predict: programmable genome- and epigenome-engineering tools for precise, durable control of gene expression — toward new therapeutic strategies.