시스템 면역 다이내믹스 연구실

Thymic T cell fate decision at the clonal level linked to the formation of the peripheral immune repertoire. Dissection of peripheral immune homeostasis shaping self/non-self decision boundaries across intracellular, intercellular, cell population, and organismal levels to better guide immunotherapies in autoimmunity and cancer. Linking (auto-)immune disease-associated GWAS SNPs and disease phenotypes in various biological layers with multiscale computational modeling to better guide immunotherapies in autoimmunity and cancer. Elucidation of dysregulated dynamical balance between anti-microbial reaction and host-detrimental inflammation in host-viral interactions in the context of SARS-CoV-2 and unknown viral species. Uncovering dynamical elements driving tumor microenvironments towards immune-suppressive states for better designing cancer immunotherapies. Exploration of adaptation (resolution vs. persistence) and memory of immune responses across scales (e.g., genetic, epigenetic, and intercellular layers) in the context of chronic inflammation (including neurodegenerative disorders), vaccine design, and aging. We are systems immunologists exploring complex immune behaviors through scalable modeling to cure immune-related diseases. Our lab is an interdisciplinary group where we learn from each other to push new frontiers. The immune system consists of multiple biological layers from genes to cells, to organs, and to organisms with many constituent players in complex interactions across scales. The immune system operates across multiple spatiotemporal scales. However, there are fundamental challenges in scalable modeling of the immune system with many constituent molecules and cells interacting across scales.