Applied Biosci & Eng Lab

Water is considered a relatively inner and stable molecule. We found that water molecules are rendered into reactive oxygen species (ROS), including OH·, H2O2, etc. The strong intrinsic interfacial electric field is in part responsible for the generation of ROS. Because ROS are highly reactive, the water microdroplet provides many new opportunities in a wide field of science and engineering. Movie: Spontaneous Generation of H2O2 in Water Microdroplet Condensates. We utilize microdroplets and microbubbles using various methods, including nebulizing spray, tip sonicator, and ultrasonic transducer. Reactive Oxygen Species (ROS) are spontaneously generated at the surface of those microdroplets and microbubbles. These ROS can be used for treating cancer because cancer cells are more vulnerable to ROS than normal cells. When ROS concentration exceeds cellular antioxidant defense capability, the reactive species exhibit an antitumor effect by inducing oxidative stress. We are working on treating cancer cells using microdroplets and microbubble technology. Metal nanostructures, including nanoparticles or nanowires, are spontaneously formed from metal precursor ions in water microdroplets without any added reducing agent, capping agent, or template. We utilize the microdroplet spray synthesis method for constructing metal or metal-organic hybrid or metal oxide nanostructured catalysts for hydrogen evolution reaction(HER), oxygen evolution reaction(OER), and oxygen reduction reaction(ORR) used for water splitting and fuel cells. Combining Mass Spectrometry Imaing(MSI) and Omics technologies enables in-depth investigation of biological processes at high resolution. MSI provides molecular distribution, while Omics identifies and quantifies molecules. Simultaneous studies of quantit