미생물-숙주 상호작용 다이나믹스 연구실

We use a multidisciplinary approach combining microbiology, molecular biology, cell biology, immunology, and pathology to understand how inflammation-dependent changes in host metabolism can result in gut dysbiosis and increased risk of non-communicable diseases. Specifically, we used various mouse models, including diet-induced-obesity, chemical-induced colitis, and germ-free animals, to identify metabolic pathways in the gut bacteria and in the host response to microbiota-derived metabolites that will aid in the prevention of human diseases. Our group also tries to figure out the mechanisms by which gut microbes adapt and overcome this harsh intestinal inflammation condition by regulating their metabolism and gene expression. Our group focuses on how intestinal inflammation caused by the bacterial pathogen Salmonella enterica serovar Typhimurium induces changes in host physiology and how these changes can cause disruption of the microbial ecosystem (microbiota) in our large intestine and promote pathogen colonization and disease. 우리 연구실은 병원성 세균 Salmonella enterica serovar Typhimurium 감염에 의해 유발되는 장내 염증 환경이 숙주의 생리적 변화를 어떻게 이끌어내는지, 그리고 이러한 변화가 장내 미생물 생태계(Gut microbiota)를 교란시키고, 병원균의 장내 증식과 최종적으로 질병 발현에 어떤 영향을 미치는지를 분자 수준에서 연구하고 있습니다.