마이크로바이옴·세포신호전달 연구실

다양한 실험 모델 시스템과 멀티오믹스 통합 분석을 통해 숙주 장내 환경 변화를 체계적으로 이해하고, 미생물–숙주 상호작용의 분자 기전을 규명합니다. It is becoming evident that microbiota can directly signal to the host by generating bioactive metabolites, which would contribute to the development (i.e., imidazole propionate) or amelioration of metabolic diseases (i.e., short-chain fatty acids). In our lab, we aim to identify therapeutics for metabolic diseases including diabetes and cancer based on mechanistic understanding of the role of microbial metabolites. In addition, we will investigate inter-individual variations or failure in drug response in the context of microbial metabolite milieu by using organoids as a model system.