세포면역유전체학 연구실

LLPS (liquid-liquid phase separation) is a phenomenon wherein macromolecules within a solution undergo de-mixing, resulting in the compartmentalization of cellular spaces in the absence of membranes. However, when LLPS occurs on or near membranes, it induces curvature deformation and interferes with the natural functions of the membrane. The protein or lipid components of membranes, as well as the membrane itself, play a crucial role in influencing the dynamics of molecular condensates. They can either facilitate the assembly reactions or lower the critical concentrations required for phase separation. In our laboratory, we are currently engaged in the exploration of cellular events and their regulation, specifically focusing on molecular condensates bound to intracellular membranes. We aims to unravel the intricate interplay between these condensates and membranes, understanding their impact on cellular processes and potentially for manipulating cellular behavior. 액체-액체 상분리 (LLPS: Liquid-liquid phase separation)는 수용성의 거대 생체 분자들이 세포질 혹은 핵질내에서 de-mixing 됨으로서, 막을 이용하지 않으면서 기능적인 세포 내 구획화를 이루어 내는 물리적 현상이다. 본 연구실에서는 이러한 LLPS 현상이 막 상에서 일어남으로서 유도되는 생체막의 구조적, 기능적, 생리학적 변형이 세포의 다양한 활성 조절에 관여하는 분자, 세포적 기전 규명에 초점을 맞춰 연구를 진행하고 있다. The organelle contact, mediated by tethering complexes situated at the junctions between membranes of distinct organelles, plays a pivotal role in governing the biogenesis, dynamics, and homeostasis of organelles. Furthermore, it exerts control over signaling cascades and material transport within the cell. Given that a myriad of cellular activities are orchestrated at these organelle contact points, it is important to elucidate the mechanisms underlying their formation and regulation. In our laboratory, we are currently investigating membrane tethering m