합성생물학 연구실

We are interested in better understanding and exploring the design space of molecular systems to achieve desired dynamical behavior in living cells. As a specific example, we have developed rationally designed RNA computing systems as genetically encodable sensors and controllers, which we call ‘ribocomputing systems’ (Green*, Kim* et al, Nature; Kim et al, Biochemistry). This work builds on a recent breakthrough in nucleic-acid-based gene expression regulator, ‘toehold switch’, that provides a library of programmable, orthogonal, and high-performance parts for synthetic biology (Green et al, Cell).