생체재료 및 중개의학 연구실

– We aim to transform the way that researchers currently detect diseases through innovations in the design and development of nanomaterials-based diagnostic biosensors that could be used to detect a number of diseases with global implications, such as cancer, myocardial infarction, and pneumonia. These innovations in the platform design will involve accomplished work from my previous studies, and also development of completely new diagnostic/therapeutic biomedical nanomaterials that are multifunctional, dynamic, and capable of being triggered externally on demand for drug delivery and bioimaging. These biomedical materials provide several different types of information to cells in their environment, and thus mimic many functions of the native extracellular matrices found in tissues. This aspect of our study involves the design and syntheses of new biomedical nanomaterials, development of new processing approaches for existing biomaterials, and extensive physical and biological characterization of the resulting tissue engineering scaffolds. (ii) Study of the interdependent interactions between synthetic biomedical materials and the complex biological systems, in particular, at material-cell and material-protein interface. – We will emphasize a fundamental understanding of how synthetic nanomaterials interact with complex biological systems. The results will be then applied back to design and synthesize new biomaterials that provide desirable cues in a spatiotemporally regulated manner to regulate the gene expression of interacting cells. For example, the performance of nanoparticle drugs often depends on the sensitive interplay between the multiple functionalities of the nanoparticle and its response to the biological environment, which, in turn, can impact the transport