생무기화학 실험실

Our research lies in the interdisciplinary studies of inorganic chemistry, biochemistry, and protein engineering. We employ spectroscopic, kinetic, thermodynamic, and biochemical techniques/analysis to understand the orchestrated chemical reactions of metalloproteins and metalloenzymes. Merging inorganic cofactors with proteins can yield novel inorganic reactivities within protein space. Thus, we can design artificial metalloenzymes, explore the sequence-structure-function relationship, and simulate how metalloenzymes can emerge and evolve. Novel metal-coordination bonding or sequence modification can endow sufficient driving force for protein self-assembly. Then, we can create novel protein-based biomaterials or versatile protein scaffolds for enzyme design. We are also interested in elucidating protein sequence-function relationships. We perform bioinformatic sequence analysis and directed evolution to understand the consequences of sequence modifications in enzyme catalysis.