합성유기화학 연구실

developing novel synthetic strategies that allow us to access natural and unnatural small molecules with biomedical value. In addition to the target-oriented synthesis of natural products, we are currently investigating the unprecedented reactivity of organic molecules based on new synthetic modalities, such as transition metal catalysis, photochemical or electrochemical mode of activation. Ultimately, we aim to expand the field of synthetic organic chemistry based on understanding the mechanistic features of the developed reactivity and make a profound impact on the neighboring research area. An efficient “cross-coupling” approach offers an ideal gateway to an unexplored C(sp3)-based chemical space. Novel reactivities of transition metal catalysts play a central role here. We recently reported effective transformations of organometallic reagents that enabled the creation of a stereo-enriched C(sp3)-based chemical space in a highly convergent manner. Based on novel synthetic modalities based on the electrochemical oxidation of organic compounds, an uncharted mode of activation of organoboron reagents has been revealed. The strategy has allowed for the discovery of a universal method to introduce an array of heteroatoms on a C(sp3) reaction center. We are currently pursuing to expand the reactivity to other types of bond formation. The highly reactive nature of a radical intermediate could be exploited to enable a variety of innovative chemical transformations. Our research group is exploring novel atom transfer and redox processes to generate important radical intermediates under specialized setting. We are applying the catalytic reactivities of our research program to the synthesis of complex natural products and their analogues. Of particular interest are specifically