암 및 면역 세포 조절 연구실

본 연구실에서는 아직까지 많은 연구가 되어 있지 않은 전사 억제 인자인 Capicua (CIC)의 여러 종류의 암과 면역 질환에서 담당하는 역할을 연구하고 있습니다. CIC에 의해 직접 조절되는 target 유전자들을 발굴하여 세포 안에서 어떠한 molecular pathway들이 CIC에 의해 조절되는지 이해하고자 합니다. 궁극적으로 암과 면역 질환들의 발병 기전을 보다 잘 이해하여 치료법 개발에 기여하는 것이 우리 연구의 목적입니다. Research areas that we are interested in include cancer and immunology. We are currently investigating the role of transcriptional repressor Capicua (CIC) in cancer progression and lymphocyte development. Based on our findings, CIC negatively regulates pathogenesis of several different types of cancer including prostate, liver, breast, and colorectal cancer, and maintains immune homeostasis through modulating activation and differentiation of lymphocytes. We will uncover CIC-mediated gene expression regulatory networks in cancer and immune cells to identify novel key players in the regulation of cancer progression and immune responses. For our studies, we employ various experimental tools and skills, ranging from molecular and cellular biological approaches to in vivo mouse genetics. The main goal of our study is to provide better insights on therapeutics for cancers and immune disorders. Research areas that we are interested in include cancer and immunology. We have been identifying and investigating novel factors that regulate various immune disorders, including autoimmune diseases, sepsis, and cancers. We are also interested in castration-resistant prostate cancer development. For our studies, we employ various experimental tools and skills, ranging from molecular and cellular biology to in vivo mouse physiology. The main goal of our study is to provide better insights on therapeutics for cancers and immune disorders. 암 및 면역 세포 조절 연구실에서는 자가면역 질환을 포함한 다양한 면역 이상 질환에 대한 세포 및 분자 기전을 연구하고 있습니다. 또한, 전립선암이 어떻게 남성호르몬 비의존성을 획득하는지에 대해