바이러스 및 분자유전공학 연구실

CRISPR-Cas는 원핵생물의 후천성 면역 체계입니다. 이 시스템은 특정 박테리아와 고세균이 외부의 바이러스로부터 자신을 방어하기 위해 진화해 온 독특한 메커니즘을 포함하고 있습니다. 저희 연구 그룹은 다양한 종류의 CRISPR-Cas 체계들의 기본적인 원리 규명에 기반한 응용 연구에 초점을 맞추고 있습니다. 특히, 우리는 이 시스템이 유전자 편집 기술에 어떻게 활용될 수 있는지를 탐구하고 있으며, 그 과정에서 생물학적 이해를 넓히고 보다 효과적이고 안전한 유전자 조작 방법을 개발하는 것을 목표로 하고 있습니다. 이를 통해 농업, 의학 및 생명공학 분야에서 새로운 가능성을 열고자 합니다. We study on basic mechanisms of replication, pathogenesis and mutagenesis of human viruses, including coronaviruses (e.g. SARS-CoV-2), human herpesviruses (e.g. HCMV), and prokaryotic viruses (Bacteriophages). Our research delves into the intricate processes that govern how these viruses replicate within host cells, thus contributing to their ability to spread and cause disease. By examining the factors that influence viral pathogenesis, we aim to uncover the specific interactions between viral components and host immune responses, which are often complex and multifaceted. Furthermore, we explore how various environmental triggers, genetic predispositions, and co-infections may modulate these interactions, potentially leading to more severe disease outcomes. Moreover, our investigation into mutagenesis focuses on how genetic variations in these viruses occur and how they may impact their evolution and adaptability, particularly in response to antiviral therapies. This includes studying the mechanisms by which mutations arise and how they can confer advantages such as increased virulence or resistance to treatments. This comprehensive approach allows us to better understand not only the biology of these viruses but also their implications for public health and disease prevention, emphasizing the crucial need for ongoing research in this area. Through our findings, we hope to contribute valuable insights into the development of effective vaccin