분자신경의학 연구실

We are attempting to understand further molecular mechanisms of proliferation, migration, differentiation, and synapse formation of neurons and molecular links to neuropsychiatric disorders. We aim to understand the tightly controlled processes involved in neurogenesis, neuronal migration, neuronal maturation, and synaptic formation. Achieving precise control over these neurodevelopmental processes requires the regulation of diverse cellular mechanisms, including molecular trafficking, cytoskeleton dynamics, and subcellular organelle contact. Various studies, including multiple GWAS showed a close link between neurodevelopment and major neuropsychiatric disorders. We are particularly interested in understanding the molecular basis of schizophrenia focusing on its neurodevelopmental aspects. Some experiments investigate how those genes play roles in regulating cytoskeleton and cell signaling. Intracellular organelles are individual components that form networks and affect structural, functional cellular activation. We focus on MAM (Mitochondria-associated ER membranes), a physical contact site between the endoplasmic reticulum and mitochondria. MAM plays critical roles in calcium homeostasis, lipid biosynthesis, immune regulation, and apoptosis. In neurons, MAM modulates intracellular calcium signaling and affects neural activity, synaptic function, metabolism, and stress responses. Through these organelle interactions, we aim to understand how subcellular networks contribute to neurodevelopmental and psychiatric disorders.