김지형 연구실

CD1 molecules (CD1a, CD1b, CD1c, and CD1d) are MHC class I-like antigen-presenting molecules that present lipid-based antigens to T cells, initiating their activation. CD1-reactive T cells recognize both self and foreign lipid antigens, contributing to both innate and adaptive immune responses. Given their broad antigen recognition capacity, CD1-reactive T cells are likely to play critical roles in various immune processes, including host defense, autoimmunity, and inflammation. Our lab investigates the functions of CD1 molecules and CD1-reactive T cells across diverse mucosal immune environments. Specifically, we aim to elucidate the mechanisms underlying CD1-reactive T cell development in the thymus, identify the lipid ligands presented by CD1 molecules and their biosynthetic pathways, and determine how CD1-expressing cells and CD1-reactive T cells contribute to immune responses in inflammatory disorders, autoimmune diseases, and cancer. By uncovering these mechanisms, our research seeks to provide novel insights into CD1-mediated immunity, ultimately paving the way for innovative immunotherapeutic strategies targeting CD1-related pathways. Helicase-X (tentative name), traditionally studied in genetics, has recently garnered attention in immunology. This protein exhibits a unique ability to bind nucleic acids such as RNA and DNA and interact with essential cellular proteins and transcription factors. We hypothesize that Helicase-X could serve as a key genetic regulator within immune cells, influencing their differentiation and activation. We focus on the potential of Helicase-X to regulate critical genes necessary for immune cell functionality, ensuring proper cellular responses. Beyond genetic regulation, we are exploring its role in epigenetics, including histone ma