김학중 연구실

The research area of the MCCB laboratory covers from organic synthesis to chemical biology. As an educational platform, the students belonging to the MCCB laboratory are trained to gain profound knowledges on organic chemistry, reaction mechanisms, synthetic strategy, biochemistry, and molecular biology. In addition, updated information on the researches about total synthesis of complex molecules, medicinal chemistry, as well as chemical biology will be discussed within the group. Our ultimate goal is to discover effective therapeutic agents by harnessing the full potential of our in-house platform technologies. Currently, our research efforts are directed toward two major disease areas: cancer and mycobacterial infections—both of which represent significant and persistent challenges in modern medicine. Through our innovative approaches, we aspire to make meaningful breakthroughs that can overcome the limitations of existing therapies. Ultimately, we hope that our work will contribute to advancing human health and well-being on a global scale. One of the major bottlenecks in small molecule-based drug discovery is the identification of promising hit compounds. This process typically involves the generation of chemical libraries through synthetic chemistry and subsequent high-throughput screening to identify candidates with desirable activity profiles. Although this approach has been the cornerstone of drug discovery for decades, it remains costly, labor-intensive, and time-consuming, often requiring substantial long-term investment for each campaign. These challenges have driven the demand for innovative technologies that can streamline hit identification and accelerate early-stage drug discovery. DNA-encoded library (DEL) screening is one of the leading technologies in