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KAIST바이오및뇌공학과

MC CHOI 생물-연성물리학 / 공학 연구실

최명철 부교수 (Myung Chul Choi)

연구실 소개

이 연구실은 생물 분자의 초분자 조립체와 세포골격 단백질 및 관련 분자들의 구조와 상호작용을 연구합니다. 특히 미세소관과 관련 단백질의 구조, 튜불린 기반 분자기계와 약물 전달 응용, 지질 소포의 상호작용을 살펴봅니다. 알츠하이머 원인 단백질과 세포막 뗏목도 연구 주제이며, 가속기 X-선과 중성자 산란 등을 이용해 구조를 분석합니다.

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연구실 홈페이지의 소개

Myung Chul Choi received a B.S. in Physics from KAIST in 1998. He received his Ph.D. degree in Physics in 2005 from KAIST for his work on “Confinement Effects on Mesoscopic Structures of Macromoleules” under the supervision of Professor Mahn Won Kim (previous President of KIAS). In 2005, he joined Safinya group at UCSB as post-doc and conducted research on the structure of cytoskeletal protein derived from nerve cells. He joined the faculty of Department of Bio and Brain Engineering at KAIST in 2010. His group’s research is focused on elucidating structures and interactions of supramolecular assemblies of biological molecules. This includes a fundamental understanding of structures and interactions between cell cytoskeletal proteins and their associated molecules which leads to their distinct structures (related to their specific functions in cells) on the nanometer to the many micrometer scales. Structures are solved by combining reciprocal space and real space data resulting from X-ray/Neutron scattering, light-microscopy and electron microscopy experiments. A major project in the group has the goal of (i) understanding structures and interactions of microtubules and microtubule-associated-proteins (MAPs), (ii) engineering tubulin-based molecular machines and implication to drug delivery system, and (iii) understanding interactions of lipid vesicles using optical bottle.

원문 보기
연구 분야

생물물리학 · 바이오나노구조 · 알츠하이머 원인 단백질 · 세포막 뗏목 · 가속기 X-선 · 중성자 산란

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